Time shared ILV Methyle experiments:
3D TS-NOESY-HN-TROSY/NOESY-HC-PEP-HSQC
4D TS-HSQC-HN/HC-NOESY-HN-TROSY/HC-PEP-HSQC

Frueh et. Al. JBNMR 2006

Pulse program: see header
-First record a TS-HSQC to define your HN and HMe regions (or record an HN-TROSY and a 13C-HSQC)
use DFtstrhsqcsi
-DFtstrnoesyhsqcsi: cnst13 is SW(N), see header for more
-DFtstrhsqcnoesyhsqcsi.2: cnst13 is SW(N), chose the folding according to what you determined with the 2D-TS-HSQC. You can fold as you wish, but be careful to modify the scripts below accordingly. Typical spectral width for indirect proton, c.a. 5 ppm

Processing:
3D:extract the HN and HMe regions (in nmrPipe: ext -left, ext -right respectively)
phase each of them independantly and update the spectra parameters (e.g. SW, carriers, etc.)
 
4D:
1) Use extract4D to unlayer the data sets with the different phases:
  extract4D ser serPH1 serPH2 TD TD1 TD2 TD3 : where TDs are total number of points (real and imaginary)

in the 4D pulse program: TD detected, TD1: 1H indirect, TD2: N/C States-TPPI, TD3: N/C E/A

2) mv serPH1 PHASE1/.
   mv serPH2 PHASE2/.

3) convert to nmrPipe (e.g. in PHASE1: ./fid4D.com)

4) cd ..
5) ./add.com: will recombine the data from PHASE1 and PHASE2 in SUM and DIFF directories 
6) in each SUM and DIFF: process the 4D, using the appropriate circular shift (CS in nmrPipe) to unfold the folded region(s). This depends on what you chose to do for the adcquisition.